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目的:了解耐甲氧西林金黄色葡萄球菌(MRSA)的医院感染现状,指导临床合理选用抗生素,预防爆发流行,为临床防治提供依据。方法:对我院2005年1月~2006年12月期间,门诊和住院病人的标本中分离的179株金黄色葡萄球菌进行了MRSA感染监测,并对逐个暴露因素进行单因素卡方分析和Logistic多元回归分析,筛选出MRSA感染的危险因素。结果:MRSA总分离率为70.9%,其中,2005年检出率为60%,2006年检出率为79%;MRSA感染部位以呼吸道为主,感染科室以神经外科、ICU科、普外科为主;住院时间、侵袭性操作、使用抗生素、合并感染、入住神经外科等5个因素与MRSA感染有关联。结论:MRSA的分离率呈逐年上升趋势,侵袭性操作、抗生素的使用和神经外科是MRSA感染的3个危险因素。
Objective: To understand the status of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) nosocomial infection, to guide clinical rational use of antibiotics, to prevent outbreaks and provide the basis for clinical prevention and treatment. Methods: A total of 179 Staphylococcus aureus isolates from outpatients and inpatients from January 2005 to December 2006 in our hospital were monitored for MRSA infection. One-way chi-square analysis and Logistic Multivariate regression analysis, screening out the risk factors for MRSA infection. Results: The total separation rate of MRSA was 70.9%, of which, the detection rate in 2005 was 60% and the detection rate was 79% in 2006. The main respiratory tract was MRSA. The infection department was neurosurgery, ICU and general surgery were The main factors such as length of hospital stay, aggressive operation, use of antibiotics, co-infection and neurosurgery were associated with MRSA infection. Conclusion: The isolation rate of MRSA is increasing year by year. Invasive operation, antibiotic use and neurosurgery are the three risk factors of MRSA infection.