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目的 研究双微体（ｄｏｕｂｌｅ ｍｉｎｕｔｅｓ，ＤＭ）在膀胱移行上皮细胞癌中的表达及其意义。方法 正常对照组 １５例，膀胱移行上皮细胞癌术前术后组各１４例，采用外周静脉血全血培养，常规染色体准备，检测ＤＭ的表达，采用统计学ｘ２检验。对ＤＭ的表达与临床病理因素及预后的关系进行分析。结果 正常对照组无ＤＭ检出，术前术后组分别有３５和 ３１对ＤＭ检出，与对照有显著性差别（Ｐ＜０．０１），且集中于两例ＤＭ阳性病例，但术前术后无显著性差别（Ｐ＜０．０５）。结论ＤＭ可作为癌基因扩增的一项独立的预后指标，ＤＭ阳性患者，预后差，易复发。
Objective To study the expression and significance of double minutes (DM) in bladder transitional cell carcinoma. Methods Fifteen cases of normal control group and 14 cases of bladder transitional cell carcinoma before and after operation were treated with peripheral blood venous blood and conventional chromosomal preparation. The expression of DM was detected by statistical x2 test. The relationship between DM expression and clinical pathological factors and prognosis was analyzed. Results No DM was found in the normal control group. There were 35 and 31 pairs of DM respectively in the preoperative and postoperative groups, which were significantly different from those in the control group (P <0.01), and were concentrated in two DM positive cases. However, No significant difference after operation (P <0.05). Conclusion DM can be used as an independent prognostic indicator of oncogene amplification. Patients with DM are poor prognosis and relapse.