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研究了六氰合亚铁酸镍修饰电极对单胺类递质及其代谢产物的催化机理,首次以该 电极为色谱电化学检测器,对8种物质进行了分离测定。同时,将微渗析活体取样技术与高 效液相色谱一电化学检测联用测定了SD大鼠脑尾核处的单胺类递质及其代谢产物,并研究了 Ca2+浓度对脑中递质的影响,拓展了电分析化学在生物活体分析中的应用范围。
The catalysis mechanism of monoamine transporters and their metabolites on nickel hexacyanoferrate modified electrode was studied. For the first time, 8 kinds of materials were separated and determined by using this electrode as a chromatographic electrochemical detector. At the same time, the micro-dialysis live sampling technique and high performance liquid chromatography-electrochemical detection combined with monoamine neurotransmitters and their metabolites at the caudate nucleus of SD rats were studied, and the effect of Ca2 + concentration on neurotransmitter in the brain Influence, expand the scope of application of electroanalytical chemistry in biological living body analysis.