论文部分内容阅读
目的观察和胃汤辅助奥美拉唑治疗胃食管反流病(GERD)的疗效。方法 67例GERD患者随机分为治疗组和对照组,前者清晨顿服奥美拉唑20mg,夜间睡前服用和胃汤,对照组清晨顿服奥美拉唑20mg,疗程6周。于治疗后2、4、6周观察胃灼热、反酸、胸骨后痛等症状的缓解情况,并于6周后复查胃镜及24h食管pH值,比较两组的治愈率。结果治疗组治疗2、4、6周后总有效率分别为80.00%、85.71%、94.28%,对照组治疗2、4、6周后总有效率分别为62.50%、68.75%、71.88%,两组比较有极显著性差异(P<0.05);治疗组治疗6周后内镜下A、B、C-D级食管炎治愈率分别达82.35%、73.33%、66.67%,对照组治疗6周后内镜下A、B级食管炎内镜下治愈率分别为46.67%、37.14%,C-D级食管炎治愈率为零,两组比较有极显著性差异(P<0.05);两组治疗6周后经24h食管pH值监测,治疗组反流次数明显少于对照组(P<0.05)。结论和胃汤辅助奥美拉唑治疗GERD的疗效明显优于单用奥美拉唑者(P<0.05)。
Objective To observe the therapeutic effect of Weizhe Tang on omeprazole in the treatment of gastroesophageal reflux disease (GERD). Methods Sixty-seven patients with GERD were randomly divided into treatment group and control group. The former was treated with omeprazole 20mg in the morning and the stomach before bedtime. The control group was treated with omeprazole 20mg in the morning and served for 6 weeks. The symptoms of heartburn, acid reflux and sternal pain were observed at 2, 4 and 6 weeks after treatment. The gastroscopy and esophageal pH value of the esophagus were examined after 6 weeks. The cure rates of the two groups were compared. Results After treatment for 2, 4 and 6 weeks, the total effective rates in treatment group were 80.00%, 85.71% and 94.28%, respectively. The total effective rates in control group after treatment were 62.50%, 68.75% and 71.88% (P <0.05). After 6 weeks of treatment, the cure rates of A, B and CD-esophagitis in the treatment group were 82.35%, 73.33% and 66.67%, respectively. After 6 weeks of treatment in the control group The cure rates of endoscopic A and B grade esophagitis were 46.67% and 37.14%, respectively. The cure rate of CD grade esophagitis was zero. There was significant difference between the two groups (P <0.05) After 24-hour esophageal pH monitoring, the number of reflux in treatment group was significantly less than that in control group (P <0.05). Conclusions: The curative effect of Goup with omeprazole is better than omeprazole alone (P <0.05).