Glycosylation and an amino acid insertion in the head of hemagglutinin independently affect the anti

• 作 者: Chunyang Gu Xianying Zeng Yang
• 机 构: StateKeyLaboratoryofVeterinaryBiotechnology,DivisionofVirology
• 出 处: 中国科学:生命科学英文版
• 发表日期: 2019年1期
• 关键词: INFLUENZA virus H5N1 antigenic variation genetic basis
• 基金项目: the National Natural Science Foundation of China (31521005,31672593),the National Key R&D Program of China (2016YFD0500201,2016YFD0500203),the China Agriculture Research System (CARS-all-G12),the

Antigenic drift forces us to frequently update influenza vaccines;however, the genetic basis for antigenic variation remains largely unknown. In this study, we used clade 7.2 H5 viruses as models to explore the molecular determinants of influenza virus an