Single-cell RNA sequencing profiling of the effects of aging on alveolar stem cells

• 作 者: Tingting Lv Kewu Jiang Jiawen
• 机 构: DepartmentofPulmonaryandCriticalCareMedicine,CenterofRespiratoryMedicine,NationalClinicalResearchCen
• 出 处: 中国科学:生命科学英文版
• 发表日期: 2019年8期
• 关键词: SINGLE-CELL RNA SEQUENCING (scRNA-seq) AGING pulmonary ALVEOLAR stem cells infla
• 基金项目: supported by the National Natural Science Foundation of China(81430001 and 81870056),Beijing Major Science and Technology Projects(Z171100000417003 to N.T.).

The aging of alveolar stem cells has been linked to many chronic lung diseases, including pulmonary fibrosis. However, the effects of aging on alveolar stem cells during homeostasis and post-injury alveolar repair have not been well characterized. Here we