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目的:比较一过性脑室周围回声增强(transient periventricular echodensities,TPE)、脑室周围白质损伤(periventricular leukomalacia,PVL)和脑出血在宫内窘迫(intrauterine growth restriction,IUGR)早产儿与无宫内窘迫早产儿中发病率的差异。方法:纳入孕24周～34周之间的IUGR早产儿和无IUGR早产儿各70例。入选病例分别在第3天、2周后及相当于足月时进行超声检查,评估TPE、PVL和出血性脑损伤在两组中发病的差异。结果:IUGR新生儿首次超声检查的TPE发病率增加(P<0.001),第二次和第三次超声检查的PVL发病率增加(P<0.001)。另外,首次超声检查对照组出血性脑损伤的发病率较高(P=0.004),第三次超声检查时,对照组的发病率降低,IUGR组则增加(P=0.015)。结论:IUGR可以引起早产儿脑白质损伤的发病率增加,有必要对此类早产儿进行常规超声随访。
OBJECTIVE: To compare the effects of transient periventricular echodensities (TPE), periventricular leukomalacia (PVL) and intracerebral hemorrhage (IUGR) preterm infants with preterm labor without intrauterine distress The incidence of children in the difference. Methods: 70 pregnant women with IUGR preterm and 24 pregnant women without IUGR were enrolled. Selected cases were in the first three days, two weeks after the equivalent of full-term ultrasound and ultrasound examination, assessment of TPE, PVL and hemorrhagic brain injury in the incidence of the difference between the two groups. Results: The incidence of TPE increased at the first sonographic examination of IUGR neonates (P <0.001), and the incidence of PVL increased at the second and third sonographic examinations (P <0.001). In addition, the incidence of hemorrhagic brain injury in the first ultrasound was higher in the control group (P = 0.004). In the third ultrasound examination, the incidence of the control group decreased and that of the IUGR group increased (P = 0.015). CONCLUSIONS: IUGR can cause an increased incidence of white matter damage in preterm infants, and it is necessary to perform conventional ultrasound follow-up of such premature infants.