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目的:探讨膀胱肿瘤患者术前、术后血清中胰岛素样生长因子(IGF-1)及血管内皮生长因子(VEGF)的水平及意义。方法:采用双抗体夹心ELISA法对48例膀胱肿瘤患者及50例正常人血清中IGF-1、VEGF的检测,了解膀胱肿瘤患者在术前、术后血清中IGF-1、VEGF的水平变化,以及不同病理分级和不同浸润深度膀胱肿瘤患者血清中IGF-1、VEGF水平的异同。结果:术前、术后第7天,膀胱肿瘤患者血清中IGF-1、VEGF值明显高于正常人;术后膀胱肿瘤患者血清中的IGF-1、VEGF的水平明显低于术前水平:随着病理分级的升高或浸润深度的增加,膀胱肿瘤患者血清中IGF-1、VEGF的水平也升高;同时膀胱肿瘤患者血清中的IGF-1和VEGF水平均升高,且存在一定的正相关。结论:监测膀胱肿瘤患者血清中的IGF-1,VEGF的水平的变化,对预测肿瘤恶性潜能和肿瘤的发展情况,以及了解肿瘤的治疗效果具有重要的临床意义。
Objective: To investigate the serum levels of insulin-like growth factor (IGF-1) and vascular endothelial growth factor (VEGF) in patients with bladder cancer before and after surgery. Methods: Serum levels of IGF-1 and VEGF in 48 patients with bladder cancer and 50 normal controls were detected by double antibody sandwich ELISA. The serum levels of IGF-1 and VEGF in bladder cancer patients before and after operation were measured. As well as the similarities and differences of serum IGF-1 and VEGF levels in patients with different grade of bladder cancer and different depth of invasion. Results: The levels of IGF-1 and VEGF in serum of bladder cancer patients were significantly higher than those of normal controls on the 7th day after surgery. The serum levels of IGF-1 and VEGF in patients with bladder cancer were significantly lower than those before operation The levels of IGF-1 and VEGF in serum of patients with bladder cancer also increased with the increase of pathological grade or the depth of invasion, while the levels of IGF-1 and VEGF in serum of patients with bladder cancer were increased, and there was a certain Positive correlation. CONCLUSION: The changes of serum IGF-1 and VEGF levels in patients with bladder cancer have important clinical significance in predicting the malignant potential of tumors and the development of tumors, as well as understanding the therapeutic effect of tumors.