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目的:探讨复方赖诺普利片在健康受试者体内的药动学性质。方法:采用液质联用测定12名健康志愿者在单剂量和多剂量口服复方赖诺普利片后的人体药动学参数。结果:该法所测得峰形良好,无杂质峰干扰测定,基线平稳;另外,将多剂量与单剂量的药动学参数进行比较发现,两组的药动学参数基本一致。结论:复方赖诺普利片主要药动学参数单剂量和多剂量给药差异无显著性,赖诺普利和氢氯噻嗪在人体内不存在“蓄积现象”。
Objective: To investigate the pharmacokinetics of compound lisinopril tablets in healthy volunteers. Methods: The pharmacokinetic parameters of 12 healthy volunteers after oral administration of compound lisinopril tablets in single or multiple doses were determined by LC-MS. Results: The peak shape measured by the method was good, no impurity peak interference determination, the baseline was stable. In addition, the multi-dose and single dose pharmacokinetic parameters were compared, the two groups of pharmacokinetic parameters are basically the same. CONCLUSION: There is no significant difference in the main pharmacokinetic parameters of compound lisinopril tablets between single dose and multiple dose administration. Lisinopril and hydrochlorothiazide do not have “accumulation phenomenon” in the human body.