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众所周知,心绞痛是心肌供氧和需氧间短暂失衡所引起,心绞痛的古老治疗药为口服冠脉扩张剂以增加心肌供氧,然而双盲试验表明冠脉扩张剂不能恒定的减轻心绞痛症状,这可归咎于冠脉的窃血现象。那些缺血区内冠脉直径已达最大值,而血流仅转向于正常灌注心肌的扩张冠脉。近代治疗心绞痛方法是减少心肌需氧,需氧量主要取决于心率、心肌收缩力和左室容量,硝酸盐的作用归因于其扩血管作用,从而减少左室搏出量,但长效的硝酸盐由于有液体潴留的危害已不
It is well-known that angina pectoris is caused by a brief imbalance between myocardial oxygen supply and aerobic. The ancient remedy for angina pectoris is oral coronary dilators to increase myocardial oxygen supply. However, double-blind trials indicate that coronary dilators do not consistently reduce the symptoms of angina pectoris. Can be attributed to the phenomenon of coronary steal. Those in the ischemic area had reached their maximum coronary diameter, whereas blood flow turned only to the dilated coronary artery that normally perfused the myocardium. Modern methods of treatment of angina is to reduce myocardial oxygen demand, oxygen demand depends mainly on heart rate, myocardial contractility and left ventricular volume, the role of nitrate due to its vasodilator effect, thereby reducing left ventricular stroke volume, but long-acting Nitrate is no longer a hazard due to fluid retention