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目的探讨肾嫌色细胞癌(renal chromophobe cell carcinoma,RCCC)的临床病理学特征、免疫学表型、鉴别诊断及预后。方法从组织形态学、免疫组织化学等方面进行回顾性分析10例RCCC病例。结果 10例中男女比2∶3,平均51.1岁。肿块直径2～11 cm,切面呈浅棕色及棕褐色,镜下肿瘤主要由多角形嫌色细胞构成,呈巢状、条索状及腺泡状排列。嫌色细胞胞质呈浅嗜伊红色细网状,胞核皱缩似葡萄干。免疫表型中CK、EMA、CD 10均见阳性表达病例。结论肾嫌色细胞癌是一种少见的肾肿瘤,预后好于其他肾脏肿瘤,形态学上与嗜酸细胞性腺瘤极其相似,掌握二者之间在形态学及免疫表型方面的差异性,将有助于肿瘤的诊断及鉴别诊断。
Objective To investigate the clinicopathological, immunological phenotype, differential diagnosis and prognosis of renal chromophobe cell carcinoma (RCCC). Methods Ten cases of RCCC were retrospectively analyzed from the aspects of histomorphology and immunohistochemistry. Results 10 cases of male to female ratio of 2: 3, an average of 51.1 years old. The diameter of the tumor was 2 ~ 11 cm and the section was light brown and tan. The microscopic tumor consisted mainly of polygonal-shaped chromophobe cells in the shape of nests, cords and alveoli. Cytoplasm of chromophobe cells were shallow eugeny red fine mesh, the nucleus shrinkage like raisins. Immunophenotype CK, EMA, CD 10 were positive expression cases. Conclusions Kidney chromophobe cell carcinoma is a rare renal tumor with a better prognosis than other renal tumors. Morphology is very similar to that of eosinophilic adenoma, and the differences between the two in morphology and immunophenotype are well understood. Will help the diagnosis and differential diagnosis of tumors.