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前列腺素合成酶抑制剂,尤其是消炎痛,能阻止早产的发生,其作用甚至大于β-拟交感神经药物,且很少引起母体副作用,但由于其对胎儿有潜在的副作用,使消炎痛的应用受到限制。为研究探讨在局部抑制前列腺素的形成能否防止早产,阴道内局部用萘普生对早产的治疗效果,对6例孕27～34周的单胎妊娠患者和1例孕33周且接受羟苄羟麻黄碱治疗早产失败的三胎妊娠患者进行研究。患者均有明显的早产征象,宫颈进行性扩张和展平,胎膜完整,无绒毛膜羊膜炎的临床征象。治疗前,患者均接受超声波检查。7例患者首先输注5%葡萄糖液500ml。若宫缩继续,则将1粒含500mg萘普生栓剂置入阴道后
Prostaglandin synthase inhibitors, especially indomethacin, prevent the onset of prematurity and are even more potent than beta-sympathomimetic drugs with few maternal side effects, but because of their potential side effects on the fetus, Application is limited. In order to explore whether local inhibition of prostaglandin formation can prevent preterm labor and the efficacy of topical vaginal administration of naproxen in preterm labor, we investigated 6 pregnant women with singleton pregnancies between 27 and 34 weeks and 1 pregnant and 33 pregnant women Benzhydroxeprine treatment of premature delivery failure of three-pregnancy patients were studied. Patients have obvious signs of premature delivery, cervical expansion and flattening, complete fetal membranes, no clinical signs of chorioamnionitis. Before treatment, patients underwent ultrasound examination. Seven patients were first infused 500ml of 5% glucose solution. If the contractions continue, then a 500mg naproxen suppository into the vagina