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对４０例高血压病（ＥＨ）患者和２０例健康对照者行口服葡萄糖耐量试验，测定其血糖（ＧＳ）和血胰岛素（ＩＳ）水平，计算其释放曲线下面积（ＡＵＣＧ、ＡＵＣＩ），发现两组空腹血糖无显著差别，ＥＨ组空腹ＩＳ和服糖后ＧＳ、ＩＳ及其ＡＵＣＧ、ＡＵＣＩ均显著高于对照组。提示高血压患者存在糖耐量降低、高胰岛素血症和胰岛素抵抗。３１例ＥＨ患者接受培哚普利降压治疗４周后，糖耐量试验显示糖负荷后１ｈ、２ｈ的ＧＳ和ＡＵＣＧ及空腹与糖负荷后各点的ＩＳ和ＡＵＣＩ均较治疗前显著降低。提示培哚普利能够降低ＥＨ患者血ＩＳ水平，具有改善其胰岛素抵抗的作用。
The oral glucose tolerance test was performed in 40 patients with essential hypertension (EH) and 20 healthy controls. The levels of blood glucose (GS) and insulin (IS) were measured and the area under the release curve (AUCG, AUCI) was calculated. There was no significant difference in fasting blood glucose among groups. Fasting IS, GS, IS, AUCG and AUCI in EH group were significantly higher than those in control group. Prompted the existence of impaired glucose tolerance in patients with hypertension, hyperinsulinemia and insulin resistance. After 3 weeks of antihypertensive treatment with perindopril in 31 patients with EH, glucose tolerance test showed that GS and AUCG at 1h and 2h after glucose loading and IS and AUCI at fasting and sugar loading points were significantly lower than those before treatment. Tip perindopril can reduce the level of blood IS in patients with EH, with its role in improving insulin resistance.