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目的 :对广西肝癌高发区健康人群及肝癌患者 HBV、 HCV、 HEV、 HGV感染状况及其与肝癌的关系进行血清流行病学研究。方法 :采用 EL ISA方法检测调查对象血清中 HBs Ag、抗 - HCV、抗 - HEV、抗 - HGV,用 RT- PCR方法检测肝癌患者血清中 HGV- RNA;用成组病例 -对照研究方法分析 HBV、 HCV、 HEV及 HGV感染与肝癌的关系。结果 :HBV、 HCV、 HEV、HGV相应的肝炎病毒感染率 ,健康人群分别为 17.8% (5 1/ 2 87)、 7.3% (2 1/ 2 87)、 6 .6 % (19/ 2 87)和 5 .9% (17/ 2 87) ;肝癌患者分别为 77.8% (2 8/ 36 )、 19.4% (7/ 36 )、 8.3% (3/ 36 )、 13.9% (4/ 36 ) ,HGV- RNA检出率为 13.9% (5 / 36 )。肝癌患者 HBV、HCV感染率高于健康人群 (P <0 .0 5 ) ;研究对象 HBV、HCV、HGV感染率高于广西及国内其他地方的自然人群 ;HBV、HCV、HGV、HEV感染者患肝癌的危险性 (OR)分别为 :11.5 2 ,3.38,2 .2 6和 0 .85。结论 :广西肝癌高发地区HBV、 HCV、 HGV流行较严重 ,再次证实 HBV感染是肝癌重要危险因素 ,其次是 HCV,不能排除 HGV感染与肝癌发生有关 ,HEV感染与肝癌发生无关 ,肝炎病毒感染是广西肝癌高发重要原因之一。
Objectives: To study the sero-epidemiological study of the status of HBV, HCV, HEV, HGV infection and its relationship with hepatocellular carcinoma in healthy population and liver cancer patients in Guangxi high incidence area. Methods: Serum HBsAg, anti-HCV, anti-HEV, anti-HGV were detected by EL ISA method. HGV-RNA in serum of patients with hepatocellular carcinoma was detected by RT-PCR method; HBV was analyzed by a group case-control study. , HCV, HEV and HGV infection and liver cancer. Results: Hepatitis B virus infection rates of HBV, HCV, HEV, and HGV were 17.8% (51⁄2 87), 7.3% (2 1/287), and 6.6 % (19/87) of healthy people, respectively. And 5.9% (17 / 2 87); Liver cancer patients were 77.8% (2 8 / 36), 19.4% (7 / 36), 8.3% (3 / 36), 13.9% (4 / 36), HGV - The RNA detection rate was 13.9% (5/36). The infection rate of HBV and HCV in patients with hepatocellular carcinoma was higher than that in healthy people (P < 0.05). The infection rates of HBV, HCV, and HGV in the study subjects were higher than those in Guangxi and other places in China; those infected with HBV, HCV, HGV, and HEV were affected. The risk of liver cancer (OR) was 11.5 2, 3.38, 2.26, and 0.85, respectively. Conclusion: The prevalence of HBV, HCV, and HGV in the high incidence area of HCC in Guangxi is more serious. It is confirmed again that HBV infection is an important risk factor for HCC, followed by HCV. HGV infection cannot be excluded from the occurrence of HCC. HEV infection has nothing to do with the development of HCC. Hepatitis virus infection is in Guangxi. One of the important causes of high incidence of liver cancer.