中国人群几种主要HIV-1感染辅助受体和配体基因多态性分析

• 作 者: 冯磊 年士艳 张兴锋 徐文波
• 机 构: 玉溪市人民医院检验科,
• 出 处: 中国优生与遗传杂志
• 发表日期: 2011年10期

一、概述HIV-1感染和艾滋病的发病过程除了由病毒本身的侵袭力决定外,人体(宿主)因素同样是不可忽视的重要方面。在HIV-1感染靶细胞的过程中,病毒不仅与CD4细胞结合,还必须和辅助受体结合,才能进入靶细胞。这意味着辅助受体等位基因发生缺失突变,将使机体在基因水平上对HIV-

First, an overview of HIV-1 infection and AIDS in addition to the process of attack by the invasion of the virus itself, the human body (host) factor is also an important aspect that can not be ignored. In the process of HIV-1 infection of target cells, the virus not only binds to CD4 cells, but also binds to the accessory receptor to enter the target cell. This means that deletion mutations in the co-receptor allele will allow the body to genetically target HIV-