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目的收集河南省2014年疑似预防接种异常反应(AEFI)报告情况,分析其特征,用于评价河南省AEFI监测系统敏感性、国家免疫规划(NIP)所用疫苗的安全性以及预防接种服务质量。方法对中国免疫规划监测信息管理系统中河南省2014年报告的AEFI个案数据进行收集,采用描述性方法对相关指标进行流行病学分析。结果河南省2014年共报告AEFI个案5 114例,报告发生率10.91/10万,男性为2 944例,占57.57%;1岁以下患儿为2 348例,占报告总数的45.91%;4—9月是AEFI报告较多的月份,其中8月份报告最多;郑州、开封、洛阳等16个省辖市每个月均报告了AEFI病例;涉及到的疫苗分别为百白破(无细胞)1471例、含麻807例、乙脑(减毒)594例,绝大多数AEFI病例预后良好。结论全省AEFI异常反应主要发生在1岁以下小年龄组儿童,涉及疫苗主要为百白破(无细胞)疫苗,预防接种服务人员和儿童监护人应密切关注。
Objective To collect the report of AEFI in Henan Province in 2014 and analyze its characteristics to evaluate the sensitivity of AEFI monitoring system in Henan Province and the safety of vaccines used in the national immunization program (NIP) and the quality of vaccination services. Methods The data of AEFI cases reported by Henan Province in 2014 in China’s immunization monitoring information management system were collected, and the descriptive method was used to conduct epidemiological analysis on related indicators. Results A total of 1144 cases of AEFI were reported in Henan Province in 2014, with a reported incidence of 10.91 / 10 million, including 2 944 men (57.57%) and 2 348 children under 1 year old (45.91% of the total) September was the month with more AEFI reports, of which the most was reported in August; AEFI cases were reported every month in 16 provincial cities such as Zhengzhou, Kaifeng and Luoyang; the vaccines involved were Baobab (cell free) 1471 Cases, containing 807 cases of anesthesia, JE (attenuated) 594 cases, the vast majority of AEFI cases with good prognosis. Conclusions The abnormal AEFI in the province mainly occurs in children under 1 year of age, and the main vaccine is DTP (cell free) vaccine. Vaccinations service staffs and child guardians should pay close attention to it.