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目的比较超声造影与常规超声在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)诊断中的临床应用价值。方法拟诊PTC患者65例(65个结节),均行超声及超声造影检查,并在超声引导下行甲状腺结节穿剌活检组织病理检查。以组织病理结果为标准,比较超声与超声造影对PTC的检出率。结果活检组织病理证实PTC 43例,良性结节22例;超声诊断PTC 36例,漏诊7例,误诊为良性结节6例;超声造影诊断PTC 42例,漏诊1例,误诊为良性结节1例;与活检组织病理结果进行对照,超声诊断甲状腺结节的敏感性、特异性及准确率分别为83.7%、72.7%和80.0%,超声造影诊断PTC的敏感性、特异性及准确率分别为97.7%、95.5%和96.9%,二者比较差异均有统计学意义(P<0.05)。结论与超声比较,超声造影在PTC诊断中更具临床应用价值。
Objective To compare the clinical value of contrast-enhanced ultrasound and routine ultrasound in the diagnosis of papillary thyroid carcinoma (PTC). Methods Sixty-five PTC patients (65 nodules) were enrolled in this study. All patients underwent ultrasound and contrast-enhanced ultrasonography. Tissue biopsy was performed under the guidance of ultrasound. Histopathological results as the standard, compared ultrasound and contrast-enhanced ultrasound detection of PTC. Results The biopsy showed 43 cases of PTC and 22 cases of benign nodules. Ultrasound diagnosis of PTC in 36 cases, missed diagnosis in 7 cases and misdiagnosis of benign nodules in 6 cases. Contrast - enhanced ultrasonography in 42 cases of PTC, missed diagnosis in 1 case and misdiagnosis of benign nodules The sensitivity, specificity and accuracy of ultrasonic diagnosis of thyroid nodules were 83.7%, 72.7% and 80.0% respectively. The sensitivity, specificity and accuracy of contrast-enhanced ultrasonography in the diagnosis of PTC were 97.7%, 95.5% and 96.9%, respectively, with significant difference between the two groups (P <0.05). Conclusion Compared with ultrasound, contrast-enhanced ultrasound in the diagnosis of PTC more clinical value.