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用电子活动仪测定给药前后小鼠的活动情况.结果证明,静脉注射2.5或10mg/kg安吖啶后小鼠活动正常,无不良反应.在5只麻醉兔中用多导生理记录仪连续观察了给予3种不同剂量安吖啶后对血压、呼吸及心电图的影响.结果表明,给小鼠静脉注射最大有效剂量4.4mg/kg,对血压、呼吸无影响,心电图也未发现异常.静脉注射10mg/kg后,2/5兔中有一过性血压下降,伴有心电图一过性Ⅱ°房室传导阻滞.给予30mg/kg(急性致死剂量),3/3兔中均引起血压下降,除Ⅱ°房室传导阻滞外,还出现室性期外收缩.在6只家兔中采用台盼蓝试验,观察了药物对组织的刺激作用.结果表明,未经5%葡萄糖稀释的高浓度组(0.5%,0.2%),注射后4～24h.对皮肤、肌肉及血管有较强刺激性,而其他低浓度组(0.1%,0.03%,0.015%)对皮肤及血管无任何刺激.
The activity of the mice before and after the administration was measured by the electronic activity meter.The results showed that the mouse activity was normal and no adverse reaction after intravenous injection of 2.5 or 10 mg / kg of amsacrine.Using a multi-channel physiological recorder in 5 anesthetized rabbits continuously Blood pressure, respiration and electrocardiogram were observed after administration of three different doses of amsacrine.The results showed that intravenous injection of the maximum effective dose of 4.4mg / kg had no effect on blood pressure and respiration and no abnormal electrocardiogram There was a transient decrease in blood pressure in 2 of 5 rabbits following injection of 10 mg / kg, accompanied by a transient ECG of ° ° AVG.At 30 mg / kg (acute lethal dose), all three thirds of rabbits caused a drop in blood pressure , In addition to Ⅱ ° atrioventricular block, but also appeared extra-ventricular contraction in 6 rabbits using trypan blue test observed the effect of drugs on tissue stimulation.The results showed that without 5% glucose dilution High concentration group (0.5%, 0.2%), 4 ~ 24h after injection. Strong irritation to skin, muscle and blood vessels, while other low concentration groups (0.1%, 0.03%, 0.015% stimulate.