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当脑膜炎球菌在体内和限铁条件下生长时,能表达脑膜炎球菌铁调节外膜蛋白,包括运铁蛋白结合蛋白1和2(Tbpl和Tbp2).Tbp是人运铁蛋白的高特异性受体,在人类和动物中有免疫原性,并且暴露于细菌表面.因此菌苗研制者试图将TbP掺入到脑膜炎球菌外膜菌苗中去.作者用SD株的纯化Tbp1/Tbp2复合物制备家免和小鼠抗SD株Tbp的多克隆单特异性抗血清,结果显示,此抗血清在免疫印迹中与不同血清群、型和亚型的异源菌株的Tbp1和/Tbp2间存在不同程度的交叉反
When meningococci are grown in vivo and under limited iron conditions, they express the meningococcal iron-regulated outer membrane proteins, including transferrin-binding proteins 1 and 2 (Tbpl and Tbp2) .Tbp is the high specificity of human transferrin Receptors, are immunogenic in humans and animals and are exposed on the surface of bacteria, so vaccine makers attempt to incorporate TbP into meningococcal outer membrane vaccine. The authors used the purified Tbp1 / Tbp2 complex of the SD strain The polyclonal monospecific antisera of home-and mouse anti-SD strain Tbp were prepared and the results showed that this antisera was found between Tbp1 and / Tbp2 of the heterologous strains of different serogroups, types and subtypes in the immunoblot Different degrees of cross-counter