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曾报道用恶性疟Santa Lucia株在A.l.griseimembra夜猴体内进行抗子孢子感染候选疫苗的可行性研究。鉴于该猴来源不足,本文作者报道用来源于秘鲁的A.vociferans夜猴作为传播阻断疫苗试验模型的可能性。 于1975年自一3岁女孩分离获得恶性疟原虫Santa Lucia株,它已成为实验室研究的标准虫株。虫株经静脉接种感染A.vociferans猴。弗氏按蚊(Anopheles freeborni)通过直接叮咬猴腹部获得感染。将感染蚊置25±1℃相对湿度60％的条件下供给糖水,喂
The feasibility study of anti-sporozoite vaccine candidate vaccine against P. l.griseimembra was studied in Santa Lucia strain of P. falciparum. In view of the lack of availability of the monkeys, the authors report the possibility of using A. vociferans as a night monkey from Peru as a model for the transmission of a blockade vaccine. The Santa Lucia strain of Plasmodium falciparum was isolated from a 3-year-old girl in 1975 and has become the standard strain of laboratory research. Insect strains were intravenously infected with A.vociferans monkeys. Anopheles freeborni gets infected by direct bite of the monkey’s abdomen. Will be infected with mosquito 25 ± 1 ℃ relative humidity of 60% of the conditions of supply of sugar, feed