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丙型肝炎病毒(HCV)大多是通过输血和血液制品传播。但在一些散发病例,HCV也可以通过其他途径如粘膜表面传播。粘膜表面分泌物中的主要免疫球蛋白是IgA,它能中和病毒,阻止病毒在粘膜表面粘附。IgA降低与经常性呼吸道及胃肠道感染有关。为了评估IgA在HCV感染中的作用,作者分析了抗-HCV阳性慢性肝炎病人的免疫球蛋白水平,发现部分病例在HCV感染前后出现IgA降低。 研究对象为94例抗-HCV阳性的病人。经肝活检证实的45例中,包括肝硬变22例,
Hepatitis C virus (HCV) is mostly transmitted by blood transfusions and blood products. However, in some sporadic cases, HCV can also be transmitted through other means, such as the mucosal surface. The major immunoglobulin in mucosal surface secretions is IgA, which neutralizes the virus and prevents the virus from sticking to mucosal surfaces. Reduced IgA is associated with recurrent respiratory and gastrointestinal infections. To assess the role of IgA in HCV infection, the authors analyzed immunoglobulin levels in patients with anti-HCV-positive chronic hepatitis and found that in some cases, IgA decreased before and after HCV infection. The subjects were 94 anti-HCV positive patients. Of the 45 cases confirmed by liver biopsy, including 22 cases of cirrhosis,