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目的了解福州市肺结核患者对抗结核药物的耐药情况,为福州市结核病防治提供科学依据。方法对福州市5个监测点就诊的结核病患者,采用WHO/IUATLD推荐的比例法进行利福平(RFP)、异烟肼(INH)、链霉素(SM)、乙胺丁醇(EMB)、卡那霉素(Km)和左氧氟沙星(OFX)的药物敏感实验。结果 203株结核分枝杆菌中,总耐药率为24.1%,耐多药率为3.4%,广泛耐药率为0.5%,其中初始耐药率和耐多药率分别为22.6%和1.8%,获得性耐药率和耐多药率分别为30.8%和10.3%。结论福州市结核耐药水平较低,但外源性感染较为严重且呈年轻化趋势。应尽早全面开展结核病耐药的检测,同时引入快速、可靠的耐药新诊断技术。
Objective To understand the resistance of tuberculosis patients to tuberculosis in Fuzhou and to provide a scientific basis for prevention and control of tuberculosis in Fuzhou. Methods RFP, INH, EMB, EMB were used in TB patients treated at 5 monitoring sites in Fuzhou. , Kanamycin (Km) and levofloxacin (OFX) drug-sensitive experiments. Results Among the 203 strains of Mycobacterium tuberculosis, the total drug resistance rate was 24.1%, the multidrug resistance rate was 3.4% and the extensive drug resistance rate was 0.5%. The initial drug resistance and multidrug resistance rates were respectively 22.6% and 1.8% , Acquired resistance rate and multidrug-resistant rate were 30.8% and 10.3% respectively. Conclusion The level of tuberculosis resistance in Fuzhou is low, but exogenous infection is more serious and younger. Tuberculosis resistance testing should be fully conducted as soon as possible, along with a rapid and reliable new diagnostic technique for resistance.