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目的探讨精子DNA碎片率与孕早期自发性流产的关系。方法前瞻性、病例对照方法,比较妻有孕早期自发性流产史的男性与妻无流产史不育男性精子DNA碎片率之间的差异。结果研究组37例,对照组43例,两组间精子DNA碎片率差异无显著性;男性年龄与精子DNA碎片率间存在正相关,与自发性流产无相关。结论精子DNA碎片率与孕早期自发性流产间无明确相关性。
Objective To investigate the relationship between sperm DNA fragmentation rate and spontaneous abortion in early pregnancy. Methods A prospective and case-control study was conducted to compare the differences in sperm DNA fragmentation rates between male and non-abortion men who had a history of spontaneous abortion during early pregnancy. Results There were 37 cases in the study group and 43 cases in the control group. There was no significant difference in sperm DNA fragmentation rate between the two groups. There was a positive correlation between male age and sperm DNA fragmentation rate and no correlation with spontaneous abortion. Conclusion There is no clear correlation between sperm DNA fragmentation rate and spontaneous abortion during early pregnancy.