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目的评估胎儿血清β2微球蛋白水平与先天性巨细胞病毒感染和风疹病毒感染的关系。方法回顾性分析巨细胞病毒与风疹病毒感染胎儿血清的β2微球蛋白水平,并与病毒IgM阴性的对照组进行比较。β2微球蛋白水平的截断值为5mg/L。结果 15例先天性巨细胞感染的胎儿,有13例血清β2微球蛋白明显升高(敏感性为86.7%);35例对照组的血清中,有32例β2微球蛋白水平低于截断值(特异性为91.4%)。8例风疹病毒感染的胎儿,血清β2微球蛋白均明显升高(敏感性为100%);15例对照组的血清β2微球蛋白水平均低于截断值(特异性为100%)。病例组与对照组比较,均具有显著统计学意义。结论对于先天性巨细胞病毒和风疹病毒感染,胎儿血清β2微球蛋白可作为一种有效的辅助性标志物,对胎儿宫内感染的诊断与评估提供参考指标。
Objective To evaluate the relationship between fetal serum β2 microglobulin level and congenital cytomegalovirus infection and rubella virus infection. Methods The β2-microglobulin levels of cytomegalovirus and rubella virus-infected fetus serum were retrospectively analyzed and compared with the negative control group. The cut-off value for β2 microglobulin was 5 mg / L. Results Fifteen cases of congenital cytomegalovirus infection in fetus, 13 cases of serum β2 microglobulin was significantly higher (sensitivity was 86.7%); 35 cases of control serum, 32 cases of β2 microglobulin levels below the cut-off value (91.4% specificity). 8 cases of rubella virus infected fetus, serum β2 microglobulin were significantly increased (sensitivity was 100%); 15 cases of control serum β2 microglobulin levels were lower than the cut-off value (100% specificity). Case group and control group, were statistically significant. Conclusions For congenital cytomegalovirus and rubella virus infection, fetal serum β2-microglobulin can be used as an effective auxiliary marker to provide a reference index for the diagnosis and evaluation of intrauterine infection.