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癌症是严重危害人类健康的一大顽症。根据世界卫生组织曾披露的癌症发展趋势表明,预计2015年发达国家癌症死亡人数将为300万人,发展中国家为600万人,全年预计死亡人数达900万人。化疗是治疗癌症的重要手段, 但是其副作用较大,于是寻求高效、低毒的抗癌药物是研究者们奋斗的目标。20世纪60年代,Rosenberg最先发现铂配合物对于肿瘤细胞生长具有抑制作用并开发了铂类配合物治疗肿瘤细胞的研究。日本学者1971年发现Ge-132 具有广泛抗癌活性以来,有机锗化学尤其对有机锗化合物抗癌活性的研究得到了空前的发展。经过化学家的努力, 发现周期表中许多金属化合物具有抗癌活性,随着人
Cancer is a major chronic problem that seriously endangers human health. According to the World Health Organization’s published cancer trends, it is estimated that cancer deaths are expected to reach 3 million in developed countries in 2015, 6 million in developing countries and an estimated 9 million deaths in the full year. Chemotherapy is an important treatment for cancer, but its side effects are greater. Therefore, it is the goal of researchers to seek efficient and low toxicity anticancer drugs. In the 1960s, Rosenberg first found that platinum complexes have an inhibitory effect on the growth of tumor cells and developed platinum complexes to treat tumor cells. Japanese scholars in 1971 found that Ge-132 has a wide range of anti-cancer activity since, organic germanium chemistry, especially organic germanium compounds anti-cancer activity has been an unprecedented development. After the efforts of chemists, found that many of the periodic table of the metal compounds with anti-cancer activity, as people