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目的比较氯氮平、利培酮、氯丙嗪对精神分裂症患者糖代谢影响的差异。方法120例首发精神分裂症患者,随机分为3组,分别接受氯氮平(氯氮平组)、利培酮(利培酮组)及氯丙嗪(氯丙嗪组)治疗,疗程6周。检测治疗前、治疗后6周空腹血糖(FPG)、糖耐量试验2小时血糖值(2HPG)。结果1组内比较,治疗前、后FPG无显著差异(P>0.05);治疗后2HPG高于治疗前(分别P<0.001,P<0.05);2组间比较,氯氮平组治疗后2HPG[(7.88±1.11)mmol/L],高于氯丙嗪组[(7.32±0.98)mmol/L]及利培酮组[(7.29±1.04)mmol/L](均P<0.05),而后两组间无显著差异(P>0.05)。结论氯氮平、利培酮、氯丙嗪对糖代谢的影响以2HPG为主,且氯氮平的影响大于利培酮及氯丙嗪。
Objective To compare the effects of clozapine, risperidone and chlorpromazine on glycometabolism in schizophrenics. Methods One hundred and twenty patients with first-episode schizophrenia were randomly divided into three groups and were treated with clozapine (clozapine), risperidone (risperidone) and chlorpromazine (chlorpromazine) week. Fasting blood glucose (FPG) and glucose tolerance test (2h) blood glucose level (2HPG) were measured 6 weeks after treatment. Results Compared with before treatment and after treatment, there was no significant difference in FPG between the two groups before treatment (P> 0.05); 2HPG after treatment was higher than before treatment (P <0.001, P <0.05, respectively) [(7.88 ± 1.11) mmol / L], higher than that in the chlorpromazine group [(7.32 ± 0.98) mmol / L] and the risperidone group (7.29 ± 1.04 mmol / L) No significant difference between the two groups (P> 0.05). Conclusions The effects of clozapine, risperidone and chlorpromazine on glycometabolism are mainly 2HPG, and clozapine is more effective than risperidone and chlorpromazine.