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目的 :观察中药白花前胡对急性心肌梗塞 (AMI)的影响。方法 :用结扎麻醉开胸猫左冠状动脉前降支诱发 AMI模型 ,于结扎后 10 min经 12指肠给药 ,做冠脉循环及心脏血流动力学 ,心肌耗氧量 ,心外膜电图 ,血清酶活性 ,组织 N- BT染色以及 AMI程度 (Σ- ST)和范围 (N- ST)等检测。结果 :白花前胡醇提物增加冠脉流量 ,降低冠脉阻力、左室压、左室舒张末压、左室最大上升速率、心率、心肌耗氧量、心肌氧摄取率和率压积。给药 (0 .2 g/kg)后 1h,血清乳酸脱氢酶和心肌 MB型肌酸激酶的变化率 ,由对照组的 (6 1.1± 12 .8) %和 (191.1± 2 2 5 .2 ) % ,分别降至(9.1± 44 .6 ) % ,P <0 .0 5和 (- 1.5± 87.2 ) % ;Σ- ST和 N - ST由 (34 .7± 41.2 ) %和 (5 3.6± 8.6 ) % ,分别降至(- 19.0± 15 .4) % ,P <0 .0 5和 (2 2 .2± 4.3) % ,P <0 .0 1;给药后 5 h,左室梗塞率由 (2 3.6± 6 .7) % ,减至 (15 .0±5 .7) % ,P<0 .0 5。结论 :中药白花前胡有抗急性心肌梗塞作用。
Objective: To observe the effect of Chinese medicine Peucedanum on acute myocardial infarction (AMI). Methods: AMI model was induced by ligation of the left anterior descending artery in thoracotomy cats and perfused with 12 intestine 10 min after ligation. Coronary circulation and cardiac hemodynamics, myocardial oxygen consumption, epicardial electricity Serum enzyme activity, tissue N-BT staining and AMI (Σ-ST) and range (N-ST) were measured. Results: Alcohol extract of Baihua Qian before increasing coronary flow, reducing coronary resistance, left ventricular pressure, left ventricular end - diastolic pressure, maximum rate of left ventricular ascending, heart rate, myocardial oxygen consumption, myocardial oxygen uptake rate and rate pressure product. The rate of change of serum lactate dehydrogenase and myocardial creatine kinase type MB were (6 1.1 ± 12.8)% and (191.1 ± 225)% in the control group, respectively, at 1 h after administration (0.2 g / kg) (34.7 ± 41.2)% and (-5.2 ± 87.2)%, respectively, and (34.7 ± 41.2)% and 3.6 ± 8.6%, respectively, to -19.0 ± 15.4%, P <0.05 and (22.2 ± 4.3)%, P <0.01; The rate of infarction was decreased from (23.6 ± 6.7)% to (15.0 ± 5.7)%, P <0.05. Conclusion: Chinese white Peucedanum has anti-acute myocardial infarction.