A Method to Accelerate the Gelation of Disulfide-crosslinked Hydrogels

• 作 者: Xiaoshan Yan Xiaotong Yang 童新明 黄延宾
• 机 构: Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering,Tsinghua University,
• 出 处: Chinese Journal of Polymer Science
• 发表日期: 2015年01期
• 关键词: GSSG disulfide glutathione minutes glycol swelling thiol accelerator physiologic

A glutathione-disulfide-ended poly(ethylene glycol)(GSSG-PEG-GSSG) was designed. It is a much more efficient accelerator than glutathione disulfide(GSSG) for the gelation of an 8arm-PEG-SH polymer solution, and the gelation time can be tuned from hours to minutes at the physiological p H and temperature. A mechanism was proposed to explain the different behaviors of the GSSG and GSSG-PEG-GSSG gelation systems. Due to the ever-going thiol-disulfide exchange reaction, the thiol-disulfide hydrogels also showed interesting swelling behavior.

A glutathione-disulfide-ended poly (ethylene glycol) (GSSG-PEG-GSSG) was designed. It is a much more efficient accelerator than glutathione disulfide (GSSG) for the gelation of an 8arm-PEG-SH polymer solution, time can be tuned from hours to minutes at the physiological p H and temperature. A mechanism was proposed to explain the different behaviors of the GSSG and GSSG-PEG-GSSG gelation systems. Due to the ever-going thiol-disulfide exchange reaction, the thiol-disulfide hydrogels also has interesting behavior.