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血吸虫病是一种严重危害人民身体健康的人畜共患寄生虫病,当前,血吸虫疫苗的研究仍是世界性难题,迄今为止,还没有一种理想的疫苗可用于免疫预防以阻断血吸虫病的传播。近年来随着生物化学、分子生物学、免疫学等学科的飞速发展,人们对血吸虫疫苗的研究工作也取得了很大的进展,目前各国研究的焦点主要集中在疫苗候选分子方面。对近年来有前途的几种血吸虫疫苗的研究进展予以综述。
Schistosomiasis is a zoonotic parasitic disease that seriously endangers people’s health. At present, the study of schistosoma vaccine is still a worldwide problem. So far, no ideal vaccine has been available for immunization to prevent schistosomiasis spread. In recent years, with the rapid development of biochemistry, molecular biology, immunology and other disciplines, great progress has been made in the research of schistosoma vaccine. At present, the research focus of all countries focuses on vaccine candidate molecules. The research progress of several promising schistosome vaccines in recent years is reviewed.