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用催眠药理指标探讨了天麻钩藤饮等平肝熄风三方的体内药物动力学过程与参数。三方对戊巴比妥钠小鼠催眠效应均有协同作用,并呈显著的量效关系。天麻钩藤饮的最低起效剂量为026g/kgig,相当於临床等效剂量的效应消退半衰期为077小时,效应维持时间为1606小时,体存血药浓度达峰时间为210小时;镇肝熄风汤相应为053g/kg,032小时,1061小时,158小时;建瓴汤相应为012g/kg,074小时,780小时,249小时
Hypnotic pharmacological indicators were used to explore the Tianma Gouteng Ping Pinggan Xifeng tripartite pharmacokinetic process and parameters. The three parties have a synergistic effect on the hypnotic effect of pentobarbital sodium mice, and showed a significant dose-effect relationship. Tianma Gouteng Decoction minimum effective dose of 0 26g / kgig, equivalent to the clinical equivalent dose of the half-life regression effect was 0 77 hours, the effect of maintaining time was 16 06 hours, the peak time for the body blood concentration of 2 10 hours; Zhengan Xifeng decoction corresponding 0 53g / kg, 0 32 hours, 10 61 hours, 1 58 hours; Jian 瓴 soup corresponding to 0 12g / kg, 0 74 hours, 7 80 hours, 2 49 hours