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目的 探讨降纤酶对进展性缺血性脑卒中的预防作用。方法 将起病在 72h内的 2 0 3例脑梗塞患者随机分成降纤酶治疗组及常规治疗组。降纤酶组在常规治疗的基础上加用降纤酶 ,治疗前后检测血液流变学各项指标 ,同时对进展性缺血性脑卒中患者的神经功能缺损进行评分。结果 降纤酶组 10例发生进展性缺血性脑卒中 ,常规治疗组 2 4例 ,两组比较有显著性差异 (P <0 .0 5 ) ;降纤酶组发生的进展性脑卒中的进展的严重程度比常规治疗组轻 (P <0 .0 1) ;近期预后较常规治疗组好 (P <0 .0 5 ) ;降纤酶治疗能明显降低血液流变学各项指标。结论 降纤酶治疗能降低进展性缺血性脑卒中发生率 ,有利于进展性缺血性脑卒中患者神经功能的恢复。
Objective To investigate the preventive effect of defibrase on progressive ischemic stroke. Methods Twenty-three patients with cerebral infarction within 72h after onset were randomly divided into defibrase-treated group and conventional treatment group. Defibrase group in addition to conventional treatment with defibrase, hemorheology before and after treatment to detect various indicators, at the same time in patients with progressive ischemic stroke neurological deficit score. Results 10 cases of defibrase in progressing ischemic stroke, the conventional treatment group of 24 cases, the two groups were significantly different (P <0. 05); defibrase group of progressive stroke The severity of the progression was lower than that of the conventional treatment group (P <0.01). The prognosis of the patients was better than that of the conventional treatment group (P <0.05). The defibrase treatment significantly reduced the indexes of hemorheology. Conclusion Defibrase treatment can reduce the incidence of progressive ischemic stroke and is conducive to the recovery of neurological function in patients with progressive ischemic stroke.