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目的建立稳定的模拟人类颈动脉粥样硬化性狭窄的动物模型。方法普通猪10头,采用血管内膜热空气损伤法在猪的颈总动脉上造成特定条件的损伤,然后以特定高脂饲料喂养2个月,评价猪血管狭窄程度和病理改变特点。结果实验动物无死亡,共20根血管有19根血管狭窄率≥70%,病理检查证实高脂喂养2个月后颈动脉的粥样硬化病理改变已属于较成熟的纤维斑块期。结论猪的颈动脉与人类相似程度高,按本实验方法,损伤后喂养2个月的猪颈动脉粥样硬化性狭窄程度和病理改变均较好符合颈动脉狭窄研究之实验需要。
Objective To establish a stable animal model of carotid atherosclerosis. Methods Ten ordinary pigs were killed by hot endotoxemia in pig carotid artery. The rats were then fed with special high-fat diet for 2 months to evaluate the degree of vascular stenosis and pathological changes. Results There were no deaths in experimental animals. Twenty vessels had 19 vessels stenosis ≥70%. Pathological examination confirmed that the pathological changes of carotid artery atherosclerosis after 2 months of high-fat diet belonged to the more mature fibrous plaque phase. Conclusion The carotid arteries of pigs have a high degree of similarity with humans. According to the experimental method, the degree of atherosclerotic stenosis and pathological changes in porcine carotid arteries fed 2 months after injury are in good agreement with the experimental study of carotid artery stenosis.