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目的通过动态血压检测观察缬沙坦氨氯地平片(倍博特)对老年收缩期高血压患者(ISH)的疗效及降压特点。方法 60例口服单一药物治疗未能达标的老年收缩期高血压患者,采用口服倍博特(缬沙坦80 mg+氨氯地平5 mg)1片/d,对60例患者进行24 h动态血压监测(ABPM),观察治疗前及治疗后患者24 h平均收缩压、脉压差、晨峰发生率。结果所有患者治疗后24 h平均收缩压、脉压差与治疗前比较明显降低(P<0.05),治疗后4、8周晨峰发生率分别为33.3%、21.7%,均明显低于治疗前的63.3%(P<0.05)。结论通过动态血压检测发现倍博特降压平稳、有效、持久,更加适合老年收缩期高血压的治疗。
Objective To observe the curative effect and antihypertensive effect of valsartan amlodipine (BET) on senile systolic hypertension (ISH) by ambulatory blood pressure test. Methods Sixty patients undergoing oral single-drug treatment of elderly patients with systolic hypertension were divided into two groups: one oral diclotene (Valsartan 80 mg + amlodipine 5 mg) (ABPM). The average systolic blood pressure, pulse pressure and morning peak incidence of patients before and 24 h after treatment were observed. Results The mean systolic blood pressure and pulse pressure difference of all patients at 24 h after treatment were significantly lower than those before treatment (P <0.05). The incidence rates of morning and afternoon at 4 and 8 weeks after treatment were 33.3% and 21.7%, respectively, which were significantly lower than those before treatment % (P <0.05). Conclusions The ambulatory blood pressure test shows that Betabert has a steady, effective and long-lasting antihypertensive treatment, which is more suitable for the treatment of elderly systolic hypertension.