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目的观察缬沙坦联合赖诺普利应用于原发性高血压患者治疗对其血脂和肾功能的影响。方法选择攀枝花市中心医院于2014年1月—2015年3月收治的原发性高血压患者85例作为研究对象,按照配对分组法分为两组,对照组40例,给予赖诺普利治疗,观察组45例,给予缬沙坦联合赖诺普利治疗,均连续治疗12周,比较两组患者疗效,并测定两组患者血脂及肾功能进行统计学分析。结果观察组总有效率为91.1%,显著高于对照组67.5%(P<0.05)。治疗12周后,观察组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)水平均显著低于对照组(P<0.05),高密度脂蛋白(HDL-C)水平显著高于对照组(P<0.05)。观察组肌酐(Cr)、血尿素氮(BUN)水平均低于对照组(P<0.05)。结论缬沙坦联合赖诺普利治疗原发性高血压患者疗效较佳,具有较强调脂作用,并可延缓高血压所致的肾功能损害,具有重要临床价值。
Objective To observe the effects of valsartan combined with lisinopril on blood lipid and renal function in patients with essential hypertension. Methods 85 patients with essential hypertension admitted from January 2014 to March 2015 in Panzhihua Central Hospital were divided into two groups according to the method of matching group and 40 patients in control group. Lisinopril treatment , 45 cases in the observation group were treated with valsartan and lisinopril. All patients were treated for 12 weeks. The curative effect of the two groups were compared. The blood lipid and renal function of the two groups were analyzed statistically. Results The total effective rate in observation group was 91.1%, which was significantly higher than 67.5% in control group (P <0.05). The levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) in the observation group after 12 weeks of treatment were significantly lower than those in the control group (P < ) Was significantly higher than the control group (P <0.05). The levels of creatinine (Cr) and blood urea nitrogen (BUN) in the observation group were lower than those in the control group (P <0.05). Conclusion Valsartan combined with lisinopril in the treatment of patients with essential hypertension better efficacy, with a strong lipid-lowering effect, and can delay hypertension-induced renal dysfunction, has important clinical value.