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健康者用普鲁卡因胺1000mg 后,用西米替丁300mg qid 共3天。至第4天,再用一次普鲁卡因胺,安排在2次外加的西米替丁300mg剂量之间。普鲁卡因胺的肾廓清率降低36%;总廓清率与生物利用度的比率降低28%;消除速率常数降低18%;半衰期延长24%。但其吸收却未受影响。西米替丁与普鲁卡因胺均在近端肾小管主动排泌进入尿液。还有肾也是这
Healthy people with procainamide 1000mg, with cimetidine 300mg qid for 3 days. By day 4, once more procainamide was administered between two 300 mg doses of cimetidine. The clearance rate of procainamide was reduced by 36%; the ratio of total clearance to bioavailability was reduced by 28%; the elimination rate constant was reduced by 18%; and the half-life was prolonged by 24%. But its absorption has not been affected. Cimetidine and procainamide are actively excreted in the proximal tubule into the urine. There are also kidney is this