N-acetylcysteine treats intravenous amiodarone induced liver injury

• 作 者: Matthew L Mudalel Kartikeya P Dave James P Hummel Steven F Solga
• 机 构: Department of Medicine,Division of Gastroenteorlogy,St. Luke’s University Hospital and Temple School
• 出 处: World Journal of Gastroenterology
• 发表日期: 2015年09期
• 关键词: intravenous likely implies pathogenesis hypotension enzymes distinguish toxicity

We report a case of intravenous(IV) amiodarone drug induced liver injury(DILI).The patient received IV N-acetylcysteine(NAC) which resulted in a rapid improvement in liver enzymes.While the specific mechanisms for the pathogenesis of IV amiodaroneDILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some commonality.Because IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases.

The patient received IV N-acetylcysteine ​​(NAC) which resulted in a rapid improvement in liver enzymes. Whilst the specific mechanisms for the pathogenesis of IV amiodarone DILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some commonality.Because IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases.