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本文应用流式细胞仪单克隆抗体,检测136例卵巢癌治疗前外周血T淋巴细胞亚群与正常对照组比较,T_4、T_8亚群出现紊乱;T_4/T_8值明显下降(P<0.001)。卵巢上皮性腺癌患者术后化疗随机分3组:化疗加干扰素组11例,化疗加中药组14例,单纯化疗组13例。每例接受5个疗程化疗,每次化疗前检测外周血T淋巴细胞亚群。结果显示:化疗加干扰素和配合中药组T_4/T_8值较单纯化疗组上升,同时可以减轻胃肠道反应和减少骨髓的抑制,有利于提高卵巢癌治疗的效果。
In this study, flow cytometry monoclonal antibody was used to detect the T lymphocyte subsets in peripheral blood of 136 cases of ovarian cancer before treatment. Compared with the normal control group, the T_4 and T_8 subsets were disordered; the T_4 / T_8 decreased significantly (P <0.001). Chemotherapy of ovarian epithelial adenocarcinoma patients were randomly divided into three groups: chemotherapy plus interferon group 11 cases, chemotherapy plus Chinese medicine group 14 cases, chemotherapy alone group 13 cases. Each case received 5 courses of chemotherapy, before each chemotherapy to detect peripheral blood T lymphocyte subsets. The results showed that the T_4 / T_8 value of chemotherapy combined with interferon and traditional Chinese medicine group was higher than that of chemotherapy alone, meanwhile it could reduce the gastrointestinal reaction and reduce the inhibition of bone marrow, which was beneficial to improve the effect of ovarian cancer treatment.