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新生内膜是冠状动脉支架置入术后再狭窄形成的主要原因 ,新生内膜的形成需要平滑肌细胞 (SMC)从中膜迁移至内膜 ,因此调控SMC迁移成为了防治再狭窄的治疗靶点。许多细胞因子和血管活性物质参与了这一过程 ,其中TGF β1 在球囊损伤后新生内膜形成中起着重要作用[1 ] 。IFN γ可
Neointimal formation is the main cause of restenosis after coronary stenting. Neointimal formation requires the migration of smooth muscle cells (SMCs) from the media to the intima. Therefore, the regulation of SMC migration has become a therapeutic target for the prevention and treatment of restenosis. Many cytokines and vasoactive substances are involved in this process, in which TGFβ1 plays an important role in neointima formation after balloon injury [1]. IFN γ can