论文部分内容阅读
目的:探讨我院应用地高辛的现状及影响血清地高辛浓度的因素。方法:收集2005年我院861例次血清地高辛浓度数据,并采用多元回归方法分析血清地高辛浓度和年龄、性别、血清肌酐浓度、剂量等因素的关系。结果:年龄(age)、性别(sex)、血清肌酐浓度(Scr)及剂量(dose)等4因素均对血清地高辛浓度(con)有影响(P<0.05),经多元回归分析它们的关系可以表达为:con=-0.474+0.750×dose+0.154×Scr+0.128×sex+0.003×age。结论:血清地高辛浓度个体差异较大,影响血清地高辛浓度有多种因素。对于大多数患者服用地高辛的剂量不宜>0.125mg/d,如果血清肌酐值偏高,提示患者可能有肾功能减退,应该减量服用地高辛。对于女性患者更应该仔细调整剂量,以免出现地高辛中毒。
Objective: To investigate the status quo of digoxin in our hospital and the factors influencing serum digoxin concentration. Methods: 861 cases of serum digoxin concentration in our hospital were collected in 2005, and the relationship between serum digoxin concentration and age, gender, serum creatinine concentration, dosage and other factors was analyzed by multivariate regression analysis. RESULTS: Four factors, age, sex, serum creatinine (Scr) and dose, all had effects on serum digoxin concentration (con) (P <0.05) The relationship can be expressed as: con = -0.474 + 0.750 × dose + 0.154 × Scr + 0.128 × sex + 0.003 × age. Conclusion: Individuals with different concentration of serum digoxin have different effects on serum concentration of digoxin. For most patients taking digoxin dose should not be> 0.125mg / d, if the serum creatinine value is high, suggesting that patients may have renal dysfunction, should be taking digoxin. For women patients should be carefully adjusted dose, in order to avoid digoxin poisoning.