论文部分内容阅读
目的观察伏格列波糖联合利拉鲁肽治疗2型糖尿病的临床疗效。方法选取无棣县人民医院2015年10月—2016年9月接诊的2型糖尿病患者106例,随机分为对照组和治疗组,每组各53例。对照组皮下注射利拉鲁肽注射液,起始剂量为0.6 mg/d,1周后增至1.2 mg/d,1次/d;治疗组在对照组的基础上口服伏格列波糖片,0.2 mg/次,3次/d。两组患者均治疗12周。比较治疗前后两组患者临床疗效、血糖和血脂指标水平改善情况。结果治疗后,对照组临床总有效率为81.13%,显著低于治疗组的94.34%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者空腹血糖(FPG)、早餐后2 h血糖(2 h PG)和糖化血红蛋白等血糖指标,以及三酰甘油(TG)、胆固醇(CHO)和低密度脂蛋白(LDL-C)等血脂指标水平均显著下降,同组比较差异具有统计学意义(P<0.05);且治疗组患者血糖、血脂指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论伏格列波糖联合利拉鲁肽治疗2型糖尿病临床疗效显著,可明显改善化验指标,且不良反应较少,具有一定的临床推广应用价值。
Objective To observe the clinical efficacy of voglibose combined with liraglutide in the treatment of type 2 diabetes mellitus. Methods A total of 106 type 2 diabetic patients admitted to Wudi County People’s Hospital from October 2015 to September 2016 were randomly divided into control group and treatment group, with 53 cases in each group. Control group subcutaneous injection of liraglutide injection, the initial dose of 0.6 mg / d, 1 week to 1.2 mg / d, 1 / d; the treatment group in the control group oral voglibose tablets, 0.2 mg / time, 3 times / d. Both groups were treated for 12 weeks. Before and after treatment, the clinical efficacy, blood glucose and blood lipid levels in both groups were compared. Results After treatment, the total clinical effective rate in the control group was 81.13%, which was significantly lower than 94.34% in the treatment group. The difference between the two groups was statistically significant (P <0.05). After treatment, fasting blood glucose (FPG), blood glucose (2h PG) and glycosylated hemoglobin (HbA1c) and other glycemic index, as well as triglyceride (TG), cholesterol and low density lipoprotein (P <0.05). The levels of blood glucose and blood lipid in the treatment group were significantly lower than those in the control group (P <0.05), and the difference was statistically significant . Conclusion Voglibose combined with liraglutide in the treatment of type 2 diabetes has a significant clinical effect, which can significantly improve the laboratory indexes with less adverse reactions and has certain clinical application value.