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目的探讨恶性胸腔积液患者可溶性簇分化抗原26(s CD26)和二肽蛋白酶Ⅳ(DPP-Ⅳ)的水平变化及临床意义。方法选取良、恶性胸腔积液患者各86例作为研究对象,采用酶联免疫吸附试验(ELISA)法检测sCD26浓度和DPP-Ⅳ活性。结果恶性胸腔积液组患者的sCD26、DPP-Ⅳ水平显著高于良性胸腔积液患者,差异均有统计学意义(P<0.01)。胸腔积液sCD26曲线下面积(AUC)为0.91,灵敏度为86.5%,特异度为86.6%;胸腔积液DPP-ⅣAUC为0.90,灵敏度为82.7%,特异度为85.0%。Spearman相关分析显示,胸腔积液sCD26与DPP-Ⅳ水平呈显著正相关(95%CI:0.82~0.91,r=0.72,P<0.01)。结论 sCD26和DPP-Ⅳ的检测对恶性胸腔积液鉴别诊断有一定的临床参考价值。
Objective To investigate the changes and clinical significance of soluble CD26 and DPP-Ⅳ in patients with malignant pleural effusion. Methods Totally 86 patients with benign and malignant pleural effusions were enrolled in this study. The concentrations of sCD26 and DPP-Ⅳ activity were detected by enzyme linked immunosorbent assay (ELISA). Results The levels of sCD26 and DPP-Ⅳ in patients with malignant pleural effusion were significantly higher than those in patients with benign pleural effusion (P <0.01). The area under curve of pleural effusion sCD26 (AUC) was 0.91, the sensitivity was 86.5% and the specificity was 86.6%. The pleural effusion DPP-Ⅳ AUC was 0.90, the sensitivity was 82.7% and the specificity was 85.0%. Spearman correlation analysis showed that pleural effusion sCD26 and DPP-Ⅳ levels were significantly positively correlated (95% CI: 0.82 ~ 0.91, r = 0.72, P <0.01). Conclusion The detection of sCD26 and DPP-Ⅳ has certain clinical value in the differential diagnosis of malignant pleural effusion.