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卵泡液中存在皮质醇及皮质类固醇结合球蛋白,且卵巢内存在糖皮质激素受体,这些都提示肾上腺类固醇影响卵巢的功能。为证实体外受精(IVF)过程中卵泡液中皮质醇浓度是否与患者反应程度及卵子受精相关,选择输卵管不孕或原因不明不孕妇女为对象,依据其早先IVF结果分为两组:第1组,20例为低反应组(先前IVF中获卵3个或以下,血雌二醇(E_2)浓度≤500pg/ml);第2组为良好反应组,15例(先前IVF中获卵3个以上,血E_2浓度>500 pg/ml)。所有患者年龄均在36～43岁,第1组平均年龄为38.2±4.7岁,第2组32.1±3.8岁。于周期第1d给与3.2mg促性腺激素释放激素激动剂
The presence of cortisol and corticosteroid-binding globulin in follicular fluid, and the presence of glucocorticoid receptors in the ovaries, suggest that adrenal steroids affect ovarian function. In order to confirm whether the level of cortisol in follicular fluid during IVF is related to the degree of patient response and fertilization of ovum, the subjects who fallopian tube infertility or unexplained infertility were selected and divided into two groups based on their previous IVF results: , 20 cases of low response group (3 or less oocytes in previous IVF, E2 ≤ 500 pg / ml); Group 2 was a good response group and 15 cases More than blood E2 concentration> 500 pg / ml). All patients were 36 to 43 years of age, group 1 with an average age of 38.2 ± 4.7 years and group 2 with 32.1 ± 3.8 years. On the 1st day of the cycle, 3.2 mg gonadotropin-releasing hormone agonist was administered