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以5,5’-亚甲基双水杨醛和2-(2-氨基苯胺基)-3-氰基-5-甲基噻吩为原料合成了一种新颖的含噻吩双水杨醛Schiff碱化合物5,5’-亚甲基双水杨醛缩-2-(2-氨基苯胺基)-3-氰基-5-甲基噻吩席夫碱,而5,5’-亚甲基双水杨醛由水杨醛和三聚甲醛缩合制得。元素分析和质谱结果证实,该Schiff碱的分子式为C39H30N6O2S2,红外光谱和1HNMR确证了其结构。用牛津杯琼脂扩散法测定了标题化合物的抑菌性能,结果表明,该Schiff碱对4种菌均有一定的抑制效果,质量浓度为1.5 g/L时,对大肠杆菌的抑菌环直径达15.0 mm,其抑菌活性为大肠杆菌>枯草芽孢杆菌>金黄色葡萄球菌>表皮葡萄球菌。
A novel thiophene-containing bis-salicylaldehyde Schiff base was synthesized from 5,5’-methylenebisalicylaldehyde and 2- (2-aminoanilino) -3-cyano-5-methylthiophene 5,5’-methylenebis salicylaldehyde-2- (2-aminoanilino) -3-cyano-5-methylthiophene Schiff base, while the 5,5’-methylenebis Salicylaldehyde from salicylaldehyde and paraformaldehyde condensation in the system. The results of elemental analysis and mass spectrometry confirmed that the Schiff base has the molecular formula of C39H30N6O2S2, and its structure has been confirmed by IR and 1HNMR. The antibacterial activity of the title compound was determined by the method of oxford agar diffusion. The results showed that the Schiff base had certain inhibitory effect on four kinds of bacteria. When the concentration was 1.5 g / L, the antibacterial ring diameter of E. coli reached 15.0 mm, the antibacterial activity of Escherichia coli> Bacillus subtilis> Staphylococcus aureus> Staphylococcus epidermidis.