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目的:本文旨在研究临床中肺大细胞癌(LCLC)的相关诊断以及通过总结外科手术治疗的一些经验,来进一步探讨其临床与病理特征,并对病患手术后的生存期进行了系统分析。方法回顾性的总结分析了冀中能源峰峰集团有限公司总医院自1982年2月至2010年4月间LCLC病患接受外科手术治疗的54例病患临床资料,其中:9例Ⅰa期,19例Ⅰb期,3例Ⅱa期,5例Ⅱb期,14例Ⅲa期,3例Ⅲb期,1例Ⅳ期。并对其生存率进行系统分析。结果 54例LCLC研究资料分析结果表明,1、3、5年生存率分别为74.1%、44.1%、31.6%。预后相对应的影响因素主要为TNM分期。结论 LCLC生存率低,预后相对较差、TNM分期也极大地影响着LCLC术后的生存率,而提高LCLC的早期发现率,及时进行手术是改善术后远期疗效的关键问题。
Objectives: This study aimed to investigate the clinical diagnosis of pulmonary large cell carcinoma (LCLC) and to summarize some of the surgical treatment experience to further explore its clinical and pathological features, and the survival of patients after surgery were systematically analyzed . Methods The clinical data of 54 patients who underwent surgical treatment of LCLC from February 1982 to April 2010 in Jizhong Energy Fengfeng Group General Hospital were retrospectively analyzed. Among them, 9 cases were stage Ⅰa, 19 cases of stage Ib, 3 cases of stage IIa, 5 cases of stage Ⅱ b, 14 cases of stage Ⅲ a, 3 cases of stage Ⅲ b, 1 case of stage Ⅳ. And the survival rate of a systematic analysis. Results The LCLC data of 54 cases showed that the 1, 3, 5 year survival rates were 74.1%, 44.1% and 31.6% respectively. The main influencing factors of prognosis are TNM staging. Conclusion LCLC has low survival rate and relatively poor prognosis. TNM staging also greatly affects the survival rate of LCLC. To improve the early detection rate of LCLC and timely operation is the key issue to improve long-term efficacy after LCLC.