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许多药物,特别是治疗心血管疾病的药物,可引起类似播散性红斑狼疮的综合征,其中首推普鲁卡因酰胺。本文报告3例用心得宁(Practolol)治疗心绞痛引起的播散性红斑狼疮综合征,并试图解释心得宁引起该综合征的机制。 3例患者(2女1男,年龄54、62、73岁)因心绞痛接受心得宁治疗,剂量每日300毫克至1200毫克。治疗进行约半年,发生了类似类风湿关节炎的症状,服解热止痛剂和理疗无效。检查发现体温在38℃左右,血沉为第一小时末37～120毫米,二例经类风湿关节炎因子试验呈阴性,抗核抗体试验阳性(滴定度为1/40
Many drugs, especially those used to treat cardiovascular disease, can cause syndromes similar to those of disseminated lupus erythematosus, the most prominent procainamide. This article reports three cases of Practolol for the treatment of angina pectoris-induced disseminated lupus syndrome and attempts to explain the mechanism by which prednisone causes the syndrome. Three patients (2 males and 1 males, ages 54, 62, and 73 years) received treatment with angina pectoris at doses ranging from 300 mg to 1200 mg daily. Treatment for about six months, a similar rheumatoid arthritis symptoms, antipyretic analgesics and physiotherapy invalid. Examination found that body temperature around 38 ℃, erythrocyte sedimentation rate of 37 to 120 mm at the end of the first hour, two cases were negative by rheumatoid arthritis factor test, anti-nuclear antibody test was positive (titer of 1/40