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用Ｐｕｌｓｉｎｅｌｉ法造成大鼠急性前脑缺血４０ｍｉｎ，然后开夹再灌注１ｈ．在缺血前５ｍｉｎ，再灌前５ｍｉｎ以及再灌３０ｍｉｎ时分别ｉｖ甲基黄酮醇胺（ＭＦＡ）１０和２０ｍｇ·ｋｇ－１．结果表明：ＭＦＡ的两个剂量组均可降低再灌注引起的脑钙含量增加，减轻脑水肿，抑制脂质过氧化物丙二醛生成，并缓解脑组织中乳酸脱氢酶的释放；同时明显改善脑电图，减轻大脑锥体细胞的变性坏死．提示：ＭＦＡ对大鼠急性脑缺血再灌注损伤有保护作用，其作用可能是通过降低钙在脑组织病理性累积，从而抑制进一步的脂质过氧化等病理生理变化实现的．
Acute forebrain ischemia in rats was induced by Pulsineli for 40 min, then reperfusion for 1 h. Methylethanolamine (MFA) 10 and 20 mg · kg-1 were administered at 5 min before ischemia, 5 min before reperfusion and 30 min after reperfusion, respectively. The results showed that both doses of MFA could reduce the increase of brain calcium content caused by reperfusion, reduce cerebral edema, inhibit the formation of lipid peroxides malondialdehyde, and relieve the release of lactate dehydrogenase in brain tissue; Improve EEG and reduce degeneration and necrosis of pyramidal cells in the brain. It is suggested that MFA may have a protective effect on acute cerebral ischemia-reperfusion injury in rats, and its effect may be through reducing the pathological accumulation of calcium in brain tissue and further inhibiting the pathophysiological changes such as lipid peroxidation.