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对１１２例孕３７～４２周单胎头位、无严重合并疾患、宫颈Ｂｉｓｈｏｐ评分≤４分且无产兆的初产妇，随机分为２组，每组５６例，对照组不采用任何促宫颈成熟的药物，观察组每ｄ应用蒂洛安２００ｍｇ加５０ｇ／Ｌ葡萄糖液２０ｍｌ静脉推注，连用２～３ｄ，观察蒂洛安促宫颈成熟的作用。结果：观察组宫颈评分显著升高率７１．４３％，总有效率１００％。对照组宫颈评分显著升高率１４．２９％，总有效率３５．７１％。两组对比有显著差异（Ｐ＜０．００５），观察组１ｄ自然发动宫缩率及第２ｄ１次引产成功率为６４．２９％，显著高于对照组（７．１４％）（Ｐ＜０．０１）。两组在产后出血及新生儿Ａｐｇａｒ评分等方面差异无显著性（Ｐ＞０．０５）。提示：蒂洛安有明显的促宫颈成熟作用，可缩短分娩发动时间及提高１次引产成功率，对母儿无不良影响，为一安全、有效的促宫颈成熟药物。
112 cases of 37-42 weeks of pregnancy single head position, no serious complications, cervical Bishop score ≤ 4 points and no birth merit in primiparous women were randomly divided into two groups, 56 cases in each group, the control group did not use any cervical ripening Of the drug. The observation group was treated with 20ml of tioluo 200mg plus 50g / L glucose solution intravenously every day for 2 ~ 3d to observe the effect of Tiroflavin on cervical ripening. Results: The observation group cervical score increased significantly 71.43%, the total effective rate 100%. The control group cervical score increased significantly 14.29%, the total effective rate 35.71%. There was significant difference between the two groups (P <0.005). The rate of spontaneous uterine contraction and the rate of successful induction of labor on day 2d in observation group was 64.29%, significantly higher than that in control group (7.14%, P <0. 05) .01). There was no significant difference between the two groups in postpartum hemorrhage and neonatal Apgar score (P> 0.05). Tip: Tiron has a clear role in promoting cervical maturation, can shorten the time of delivery and increase the success rate of induction of labor, no adverse effects on the mother and child, as a safe and effective cervical ripening drugs.