论文部分内容阅读
从体内外动物实验证实,血小板对冠状动脉粥样硬化及其合并症的形成均起重要作用。在人类亦已证实动脉粥样硬化患者血小板消耗增加。由于血小板在动脉内膜上粘附,聚集后释放出生长因子而促使动脉壁上平滑肌细胞增生,这是动脉粥样硬化的主要病理改变。应用血小板抑制剂,可阻止血小板消耗、平滑肌细胞增生及动脉粥样硬化的形成。临床研究中证实,防止心肌梗塞及降低病死率的血小板抑制剂主要有阿斯匹林ASA)、潘生丁(DPD)及苯(月黄)唑酮
Animal experiments from in vitro and in vivo confirmed that platelets play an important role in the formation of coronary atherosclerosis and its complications. In humans, platelet consumption has also been shown to be increased in patients with atherosclerosis. Because of the adhesion of platelets to the intima of the arteries and the release of growth factors after aggregation, they promote the proliferation of smooth muscle cells in the arterial wall, which is the major pathological change of atherosclerosis. The use of platelet inhibitors, can prevent platelet consumption, smooth muscle cell proliferation and atherosclerosis formation. Clinical studies have confirmed that to prevent myocardial infarction and reduce the mortality of platelet inhibitors mainly aspirin ASA), dipyridamole (DPD) and benzene (moon yellow)