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目前普遍认为单用组织病理作为原发性黑素瘤的预后参数的可靠性是不够的.鉴于恶性黑素瘤会出现HLA-DR抗原和96-K抗原,而且HIA-DR抗原的存在又常伴有肿瘤内淋巴细胞的浸润(ILI),因此有可能用作为该肿瘤的预后参数.为进一步弄清它们与组织病理类型、肿瘤厚度等已知预后参数之间的关系,作者用单克隆抗体和免疫组织化学技术对40个手术切除标本进行了观察.根据临床表现和组织病理诊断标准,将病变分成表浅扩散型恶黑伴放射状生长模式(RM)(21例)和侵袭浸润性恶黑伴垂直生长模式(VM)(19例)2组,又依肿瘤厚度划分为厚度<1mm(7例)和>1
It is currently widely accepted that the use of histopathology alone as a prognostic parameter for primary melanoma is not sufficient. Given the presence of HLA-DR antigen and 96-K antigen in malignant melanoma, the presence of HIA-DR antigen is often present. Associated with intratumoral lymphocyte infiltration (ILI), it may be used as a prognostic parameter of the tumor. To further understand their relationship with known pathological types, tumor thickness and other known prognostic parameters, the authors used monoclonal antibodies. Immunohistochemical technique was used to observe 40 surgical specimens. According to the clinical manifestations and histopathological diagnostic criteria, the lesions were divided into superficial diffusive type with dark radial pattern (RM) (21 cases) and invasive black With vertical growth pattern (VM) (19 cases) 2 groups, and according to tumor thickness was divided into thickness <1mm (7 cases) and> 1