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单克隆免疫球蛋白(M蛋白)是单克隆浆细胞增殖性疾病诊断、预后分析及疗效评价的核心指标。血清重轻链(HLC)检测,作为一种新兴的M蛋白定量技术,可以特异性测定重链及轻链相关的免疫球蛋白水平。近年来,HLC检测已被应用于多种单克隆浆细胞增殖性疾病的研究,给此类疾病的诊疗带来新的检测手段。《中国肿瘤临床》2016年第43卷第15期“特约综述”栏目中,特邀中国医学科学院北京协和医院血液内科科室副主任李剑教授
Monoclonal immunoglobulin (M protein) is the core indicator of the diagnosis, prognosis analysis and curative effect evaluation of monoclonal plasma cell proliferative disease. Serum heavy and light chain (HLC) detection, as a new M protein quantification technique, can specifically measure heavy chain and light chain related immunoglobulin levels. In recent years, HLC detection has been applied to a variety of monoclonal plasma cell proliferative disease research, to bring new methods of diagnosis and treatment of such diseases. “Chinese Oncology Clinical” 2016 forty-third volume 15 “” special review "column, invited Chinese Academy of Medical Sciences Peking Union Medical College Hospital Department of Hematology, deputy director of the Department of Li Jian